Skip 
Navigation Link

1215 South Walnut Ave.
Demopolis, AL 36732 map map 

Access to Care: 334.289.2410

Medical Disorders
Resources
Basic InformationLookupsLatest News
Tongue, Lip Snip Surgeries May Be Overused in U.S. NewbornsBrain Injury Often a Devastating Side Effect of Domestic ViolenceAnti-Vaccine Movement a 'Man-Made' Health Crisis, Scientists WarnWhen Traditional Rx Fails, Psoriasis Patients Seek AlternativesVets With PTSD Face Higher Odds for Early Death From Multiple CausesU.S. Cases of Infant Gut Illness Plummet After Vaccine IntroducedThe Safer Way to Ease Post-Surgical PainOverweight Kids Are at Risk for High Blood PressureAHA News: 3 Simple Steps Could Save 94 Million Lives WorldwideRace Affects Life Expectancy in Major U.S. CitiesU.S. Measles Cases for 2019 Already Exceed All Annual Totals Since 1992: CDCHigh LDL Cholesterol Tied to Early-Onset Alzheimer'sBlood Banks Could Help Screen for Hereditary High CholesterolHigh Measles Rates Mean Kids, Adults Need Proper Vaccination: CDCCPAP Brings Longer Life for Obese People With Sleep Apnea: StudyAHA News: Is Yoga Heart-Healthy? It's No Stretch to See Benefits, Science SuggestsMigraine Pain Linked to Raised Suicide RiskInsurers' Denials of Opioid Coverage Spurs CDC to Clarify GuidelinesColorado Sees Spike in ER Visits After Pot Made LegalNeed to Be Vaccinated? Try Your Local PharmacyAHA News: Opioid Meds Pose Danger to Kidney Disease PatientsMajor Flooding Can Bring Skin Infection DangersFDA Aims to Strengthen Sunscreen RulesAs U.S. Measles Outbreaks Spread, Why Does 'Anti-Vax' Movement Persist?Health Tip: Know Your Family's Medical HistoryDisrupted Sleep Plagues Hospital Patients, But New Program Might HelpClimate Change Already Hurting Human Health, Review ShowsCalling All Blood Donors …Radiation Doses From CT Scans Vary WidelyCan Herbal Drug Kratom Kill?Health Tip: Use Medical Devices SafelyDon't Let Holiday Season Stress Worsen Your Allergies, AsthmaA Family Tragedy Highlights Carbon Monoxide DangerPhysical Therapy Can Help You Avoid Opioids When Joint Pain StrikesEczema Can Drive People to Thoughts of Suicide: StudyHospitalizations Rising Among the HomelessMillions of Americans Still Breathing Secondhand Smoke: ReportMany Americans Unaware of Promise of Targeted, 'Personalized' Medicine: PollMost Americans Lie to Their DoctorsWhat's Best for Babies With Recurring Ear InfectionsAfter a Spouse's Death, Sleep Woes Up Health RisksConcussion Tied to Suicide RiskMajor Injuries Take a Toll on Mental HealthNew Cholesterol Guidelines Focus on Personalized ApproachHome Health-Care Tests: Proceed With CautionU.S. Hospitals Making Headway Against InfectionsHard Arteries Hard on the Aging Brain?Widely Used Antipsychotics May Not Ease Delirium in ICUNew Nerve Stimulation Technique Might Relieve Back PainAHA: Stiffening of Blood Vessels May Point to Dementia Risk
Questions and AnswersVideosLinksBook Reviews
Related Topics

Cancer
Men's Health
Women's Health

Widely Used Antipsychotics May Not Ease Delirium in ICU

HealthDay News
by -- Robert Preidt
Updated: Oct 22nd 2018

new article illustration

MONDAY, Oct. 22, 2018 (HealthDay News) -- Two common antipsychotic drugs are ineffective in treating delirium in intensive care unit patients, and don't shorten the length of time spent in the ICU or the hospital, a new study finds.

Despite widespread use of haloperidol or ziprasidone, "we found, after extensive investigation with medical centers all over the country, that the patients who get these potentially dangerous drugs are not experiencing any improvements whatsoever in delirium, coma, length of stay or survival," said senior author Dr. E. Wesley Ely.

He's professor of medicine at Vanderbilt University School of Medicine, in Nashville, Tenn.

"Every day, there are many thousands of patients receiving unnecessary antipsychotics in the critical care setting that are bringing risk and cost without benefit," Ely said in a university news release.

Delirium affects more than 7 million hospitalized Americans a year. It can occur in patients of any age, but is more common among older adults who have a major illness -- especially involving ICU care -- or who have major surgery.

Antipsychotic medications have been used to treat delirium in ICU patients for 40 years. But the new study "suggests the need to reexamine that practice," said Dr. Marie Bernard, deputy director of the U.S. National Institute on Aging, which funded the study. She spoke in an agency news release.

In the new study, Ely's team tracked outcomes for 566 ICU patients treated at 16 U.S. medical centers. All of the patients developed delirium and were given either intravenous haloperidol, ziprasidone or a placebo (saline). The patients had a wide range of ages and conditions.

The researchers observed no significant difference between the three groups in duration of delirium or coma, and no significant differences in 30-day or 90-day death rates, or in time spent on a ventilator, in the ICU, or in the hospital.

There was no evidence that the antipsychotics caused major harm to any patients. However, other studies have found that the drugs do come with risks and are tied to a higher risk of stroke, pneumonia, balance problems and falls in elderly patients.

Dr. Mark Astiz directs critical care medicine at Lenox Hill Hospital in New York City. He said that "patients who are being treated for life-threatening diseases frequently develop a delirium, which is complicated by agitation and behavioral changes."

The new findings are "consistent with earlier smaller clinical trials suggesting that [antipsychotics] should not be routinely used for this indication in critically ill patients," Astiz said.

The study was published online Oct. 22 in the New England Journal of Medicine.

More information

The U.S. National Library of Medicine has more on delirium.